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【Seracare產(chǎn)品介紹】

編號	英文名稱	中文名稱
JL-FA-01	Amebiasis (AME)	阿米巴病
JL-FA-02	Allergens, Rast scores	過敏原，放射性過敏原吸收實(shí)驗(yàn)。指對特定的人群引起免疫反應(yīng)或者過敏反應(yīng)的食品中的蛋白質(zhì)
JL-FA-03	Allergens, Rast scores negative	過敏原，放射性過敏原吸收實(shí)驗(yàn)陰性
JL-FA-04	Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis	抗環(huán)瓜氨酸肽抗體
JL-FA-05	ASCA Saccharomyces Cerevi	人抗釀酒酵母抗體（ASCA）
JL-FA-06	Aspergillis	麴菌病
JL-FA-07	Beta 2 Glycoprotein	β2糖蛋白
JL-FA-08	Beta 2 Glycoprotein IgM	β2糖蛋白 IGM
JL-FA-09	Bordela Pertussis	百日咳桿菌
JL-FA-10	Bordela Pertussis IgM	百日咳桿菌 IGM
JL-FA-11	C-ANCA	C-抗中性粒細(xì)胞胞漿抗體（ANCA)
JL-FA-12	Cardiolipin	心肌磷脂
JL-FA-13	Cardiolipin IgA	心肌磷脂 IGA
JL-FA-14	Cardiolipin IgG	心肌磷脂 IGG
JL-FA-15	Cardiolipin IgM	心肌磷脂 IGM
JL-FA-16	Cerebral Spinal Fluid	腦脊髓液
JL-FA-17	Chagas	恰加斯病/南美錐蟲
JL-FA-18	Chlamydia	衣原體
JL-FA-19	Chlamydia IgA	衣原體IGA
JL-FA-20	Chlamydia IgG	衣原體IGG
JL-FA-21	Chlamydia IgM	衣原體IGM
JL-FA-22	Chlamydia Neg	衣原體陰性
JL-FA-23	Clotting Factor C3	凝固因子C3
JL-FA-24	Clotting Factor C4	凝固因子C4
JL-FA-25	Coccidiodes	球孢菌
JL-FA-26	Cytomegalovirus (CMV) Neg	巨細(xì)胞病毒抗體陰性
JL-FA-27	CMV IgG	巨細(xì)胞病毒 IGG陽性
JL-FA-28	CMV IgM VCA	巨細(xì)胞病毒 IGM 陽性
JL-FA-29	C-Reactive Protein (CRP)	C-反應(yīng)蛋白質(zhì)
JL-FA-30	Dengue Fever	登革熱
JL-FA-31	Dengue Fever IgM	登革熱 IGM
JL-FA-32	DS (Double Stranded) DNA	雙鏈脫氧核糖核酸
JL-FA-33	EBNA (Epstein-Barr nuclear antigen) IgG	EB病毒核抗原 IGG
JL-FA-34	EBNA (Epstein-Barr nuclear antigen) IgM	EB病毒核抗原 IGM
JL-FA-35	Epstein Barr Virus (EBV) Negative Plasma	EB病毒陰性血漿
JL-FA-36	Epstein Barr Virus (EBV) EA IgM	EB病毒早期抗原 IGM
JL-FA-37	Epstein Barr Virus (EBV) VCA IgM	EB病毒殼蛋白 IGM
JL-FA-38	Epstein Barr Virus (EBV) EA IgG	EB病毒早期抗原 IGG
JL-FA-39	EMA (Endomysial Antibodies)	肌內(nèi)膜
JL-FA-40	Gliadin	麩蛋白,麥醇溶蛋白,麥膠蛋白
JL-FA-41	Gliadin IgG	麥醇溶蛋白 IGG
JL-FA-42	Gliadin IgA	麥醇溶蛋白 IGA
JL-FA-43	Glomerular Basement Membrane (GBMA)	腎小球基底膜病
JL-FA-44	Helicobacter pylori IgA	幽門螺旋桿菌IGA
JL-FA-45	Helicobacter pylori IgG	幽門螺旋桿菌IGG
JL-FA-46	Helicobacter pylori IgM	幽門螺旋桿菌IGM
JL-FA-47	Helicobacter pylori Negative	幽門螺旋桿菌陰性
JL-FA-48	Helicobacter pylori Positive Plasma	幽門螺旋桿菌陰性血漿
JL-FA-49	Hepatitis A Virus (HAV) Pos. Plasma	甲型肝炎病毒陽性血漿
JL-FA-50	Hepatitis A Virus (HAV) IgM	甲型肝炎病毒IGM
JL-FA-51	Hepatitis B Core (HBc) IgG	乙型肝炎病毒核心 IGG
JL-FA-52	Hepatitis B Core (HBc) IgM	乙型肝炎病毒核心 IGM
JL-FA-53	Anti Hbe (Antibody to HBV antigen)	乙肝抗體
JL-FA-54	Hepatitis Delta Virus	丁型肝炎病毒
JL-FA-55	HBeAg (HBV e antigen)	乙肝 E抗原
JL-FA-56	anti-HBs (HBV surface antibody)	乙肝表面抗體
JL-FA-57	Hepatitis B (HBsAg) "Chronic"	乙型肝炎（乙肝表面抗原）“慢性病
JL-FA-58	HBsAg (HBV surface antigen) Serum	乙肝表面抗原血清
JL-FA-59	HBsAg (AD)	乙肝表面抗原（AD）
JL-FA-60	HBsAg (AY)	乙肝表面抗原（AY）
JL-FA-61	HBV Positive Plasma	乙肝陽性血漿
JL-FA-62	HBV DNA Plasma	乙肝DNA血漿
JL-FA-63	HBV DNA Serum	乙肝DNA血清
JL-FA-64	HBV DNA type A	A型乙肝DNA
JL-FA-65	HBV DNA type B	B型乙肝DNA
JL-FA-66	HBV DNA type C	C型乙肝DNA
JL-FA-67	HBV DNA type D	D型乙肝DNA
JL-FA-68	HBV DNA type E	E型乙肝DNA
JL-FA-69	HBV DNA type F	F型乙肝DNA
JL-FA-70	HBV Antibody HCV Antibody Plasma CO-INFECTED	乙肝和丙肝聯(lián)合感染血漿
JL-FA-71	HCV (Hepatitis C Virus) Antibody	丙型肝炎抗體
JL-FA-72	HCV Core Antigen Positive	丙肝核心抗原陽性
JL-FA-73	HCV RNA PLASMA Genotype 1	基因1型丙肝RNA 血漿
JL-FA-74	HCV RNA PLASMA Genotype 2	基因2型丙肝RNA 血漿
JL-FA-75	HCV RNA PLASMA Genotype 3	基因3型丙肝RNA 血漿
JL-FA-76	HCV RNA PLASMA Genotype 4	基因4型丙肝RNA 血漿
JL-FA-77	HCV RNA PLASMA Genotype 5	基因5型丙肝RNA 血漿
JL-FA-78	HCV RNA PLASMA Genotype 6	基因6型丙肝RNA 血漿
JL-FA-79	HCV Riba single band	丙肝免疫印跡單波段
JL-FA-80	HCV RIBA Pos. (multiple bands)	丙肝免疫印跡陽性多波段
JL-FA-81	HCV Negative	丙肝陰性
JL-FA-82	HCV RNA Pos (quantitative)	丙肝RNA陽性（定量）
JL-FA-83	Hepatitis E	戊型肝炎
JL-FA-84	Herpes Simplex Virus (HSV)1/2 Positive Plasma	單純性皰疹病毒1/2陽性血漿
JL-FA-85	Herpes Simplex Virus (HSV) 1 Negative Plasma	單純性皰疹病毒1 陰性血漿
JL-FA-86	Herpes Simplex Virus (HSV) 1 IgG	單純性皰疹病毒1 IGG
JL-FA-87	Herpes Simplex Virus (HSV 1) IgM	單純性皰疹病毒1 IGM
JL-FA-88	Herpes Simplex Virus (HSV) 2 IgG	單純性皰疹病毒2 IGG
JL-FA-89	Herpes Simplex Virus (HSV) 2 IgM	單純性皰疹病毒2 IGG
JL-FA-90	Histone	組蛋白
JL-FA-91	Human Anti Mouse Ab (HAMA)	人抗鼠抗體
JL-FA-92	Human immunodeficiency virus (HIV) 1 Neg	HIV I 陰性
JL-FA-93	anti Human immunodeficiency virus (HIV) 1 Plasma	抗HIV I 血漿
JL-FA-94	anti Human immunodeficiency virus (HIV) 1 Serum	抗HIV I 血清
JL-FA-95	anti Human immunodeficiency virus (HIV) 2 Western Blot Tested	抗HIV 2 免疫印跡
JL-FA-96	anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+)	抗HIV 1/2 2 HIV陽性
JL-FA-97	Human immunodeficiency virus (HIV) Ag	HIV抗原
JL-FA-98	HIV RNA (quantitative) Plasma	HIV RNA 定量血漿
JL-FA-99	HIV RNA (quantitative) Serum	HIV RNA 定量血清
JL-FA-100	HIV1 Subtype A	HIV1 亞型A
JL-FA-101	HIV1 Subtype B	HIV1 亞型B
JL-FA-102	HIV1 Subtype C	HIV1 亞型C
JL-FA-103	HIV1 Subtype D	HIV1 亞型D
JL-FA-104	HIV1 Subtype E	HIV1 亞型E
JL-FA-105	HIV1 Subtype F	HIV1 亞型F
JL-FA-106	HIV1 Subtype G	HIV1 亞型G
JL-FA-107	HIV1 Subtype H	HIV1 亞型H
JL-FA-108	HIV1 Subtype J	HIV1 亞型J
JL-FA-109	HIV1 Subtype K	HIV1 亞型K
JL-FA-110	HIV1 Group O	HIV1 亞型O
JL-FA-111	Human immunodeficiency virus (HIV) 2 Antibody Plasma	HIV 2 抗體血漿
JL-FA-112	Human immunodeficiency virus (HIV) 2 Antibody Serum	HIV 2 抗體血清
JL-FA-113	HPV (Human Papiloma Virus) Negative	人乳狀瘤病毒HPV陰性
JL-FA-114	HPV (Human Papiloma Virus) Positive	人乳狀瘤病毒HPV陽性
JL-FA-115	Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED	HIV 抗體 HCV
JL-FA-116	Human T-cell Lymphotropic Virus (HTLV) I/II	人嗜T淋巴細(xì)胞病毒(HTLV) I/II
JL-FA-117	Human T-cell Lymphotropic Virus (HTLV) I	人嗜T淋巴細(xì)胞病毒(HTLV) I
JL-FA-118	Human T-cell Lymphotropic Virus (HTLV) II	人嗜T淋巴細(xì)胞病毒(HTLV) II
JL-FA-119	Jo-1	多發(fā)性肌炎抗原JO-1
JL-FA-120	IgE < 5,000 Ku/L	IgE < 5,000 Ku/L
JL-FA-121	Legionella	軍團(tuán)桿菌屬
JL-FA-122	Leptospira	軍團(tuán)桿菌屬
JL-FA-123	Lyme Disease	萊姆(氏)病:蜱傳播的全身性疾病,常在夏季發(fā)生
JL-FA-124	Lyme IgG	萊姆(氏)病 IGG
JL-FA-125	Lyme IgM	萊姆(氏)病 IGM
JL-FA-126	Lyme Disease Neg	萊姆(氏)病陰性
JL-FA-127	Malaria	瘧疾
JL-FA-128	Mononucleosis (infectious)	單核細(xì)胞增多癥（有傳染性的）
JL-FA-129	Mononucleosis Negative	單核細(xì)胞增多癥陰性
JL-FA-130	Measles Negative	麻疹陰性
JL-FA-131	Measles IgG	麻疹 IGG
JL-FA-132	Measles IgM	麻疹 IGM
JL-FA-133	Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL)	微粒體抗甲狀腺過氧化物酶抗體
JL-FA-134	Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma	微粒體抗甲狀腺過氧化物酶抗體
JL-FA-135	Anti-mitochondrial antibody (AMA)	抗線粒體抗體
JL-FA-136	Multiple Sclerosis	多發(fā)性硬化癥
JL-FA-137	Mumps IgG	流行性腮腺炎 IGG
JL-FA-138	Mumps Ab IgM	流行性腮腺炎抗體 IGM
JL-FA-139	Mumps Antibody Negative Plasma	流行性腮腺炎抗體陰性血漿
JL-FA-140	Mumps Antibody Negative Serum	流行性腮腺炎抗體陰性血清
JL-FA-141	Myeloma Plasma	骨髓瘤血漿
JL-FA-142	Myeloma IgA	骨髓瘤IGA
JL-FA-143	Myeloma IgE	骨髓瘤IGE
JL-FA-144	Myeloma IgG	骨髓瘤IGG
JL-FA-145	Myeloma IgM	骨髓瘤IGM
JL-FA-146	Mycoplasma	支原體
JL-FA-147	Mycoplasma Negative	支原體陰性
JL-FA-148	Mycoplasma IgG	支原體IGG
JL-FA-149	Mycoplasma IgM	支原體IGM
JL-FA-150	Mycoplasma PCR	支原體PCR
JL-FA-151	Normal Human Plasma	正常人血漿
JL-FA-152	Normal Human Serum	正常人血清
JL-FA-153	Nuclear Antibody Centromere	核抗體著絲粒
JL-FA-154	Nuclear Antibody, Speckled ANA	核抗體，斑點(diǎn)抗核抗體
JL-FA-155	Nuclear Antibody, Nucleolar ANA	核抗體,核仁抗核抗體
JL-FA-156	Nuclear Antibody, Homogeneous ANA	核抗體，同質(zhì)抗核抗體
JL-FA-157	Nuclear Antiobody, Speckled. (ANA) Negative	核抗體，斑點(diǎn)。抗核抗體陰性
JL-FA-158	P-ANCA (associated neutrophil cytoplasmic antibodies)	相關(guān)的嗜中性粒細(xì)胞胞漿抗體
JL-FA-159	Parietal Cell Antibody (PCA)	胃)壁細(xì)胞抗體
JL-FA-160	Parvo positive plasma	細(xì)小病毒陽性血漿
JL-FA-161	Parvo IgM	細(xì)小病毒 IGM
JL-FA-162	Parvo IgG	細(xì)小病毒 IGG
JL-FA-163	Parvo Negative Plasma	細(xì)小病毒陰性血漿
JL-FA-164	Parvo DNA positive	細(xì)小病毒 DNA 陽性
JL-FA-165	Phospholipid Positive Plasma	磷脂陽性血漿
JL-FA-166	Prothrombin	凝血酶原,凝血因子
JL-FA-167	Rheumatoid Factor (RF) <1000 IU/mL	類風(fēng)濕因子<1000 IU/mL
JL-FA-168	Rheumatoid Factor (RF) 1001-2000 IU/mL	類風(fēng)濕因子1001-2000 IU/mL
JL-FA-169	Rheumatoid Factor (RF) 2001-4000 IU/mL	類風(fēng)濕因子 2001-4000 IU/mL
JL-FA-170	Rheumatoid Factor (RF) 4001-5000 IU/mL	類風(fēng)濕因子 4001-5000 IU/mL
JL-FA-171	Rheumatoid Factor (RF) >5000 IU/mL	類風(fēng)濕因子>5000 IU/mL
JL-FA-172	Ribonucleoprotein (RNP) Positive	核糖核蛋白陽性
JL-FA-173	Rubella Chimeric	風(fēng)疹
JL-FA-174	Rubella Negative	風(fēng)疹陰性
JL-FA-175	Rubella IgG	風(fēng)疹I(lǐng)GG
JL-FA-176	Rubella IgM	風(fēng)疹I(lǐng)GM
JL-FA-177	Rubeola Negative Plasma	風(fēng)疹陰性血漿
JL-FA-178	Rubeola IgG	風(fēng)疹I(lǐng)GG
JL-FA-179	Scleroderma (Scl-70) Pos	膠原沉著病,硬皮病,硬皮癥陽性
JL-FA-180	Scleroderma (Scl-70) Negative	硬皮病陰性
JL-FA-181	Sickle Cell Fresh Whole Blood	鐮刀形紅細(xì)胞新鮮全血
JL-FA-182	Smith (SM)	抗Smith抗體陽性血清（SLE的特征性抗體）
JL-FA-183	SMITH RNP	抗RNP抗體陽性血清（SLE的特征性抗體）
JL-FA-184	Smooth Muscle (ASMA)	抗平滑肌抗體陽性血清
JL-FA-185	Sjogren syndrome antigen A (SSA) Positive	舍格倫綜合征或干燥綜合征抗原A 陽性
JL-FA-186	Sjogren syndrome antigen B (SSB) Positive	舍格倫綜合征抗原B 陽性
JL-FA-187	Sjogren syndrome antigen B (SSB) Negative	舍格倫綜合征抗原B陰性
JL-FA-188	Streptolysin O Ab (ASO)	鏈球菌溶血素O抗體
JL-FA-189	Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma	梅毒（梅毒-快速血漿反應(yīng)）陽性血漿
JL-FA-190	Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma	梅毒（梅毒-快速血漿反應(yīng)）陰性血漿
JL-FA-191	Syphilis/ATA/T. pallidum IgG	梅毒ATA/T，蒼白球IGG
JL-FA-192	Syphilis/ATA/T. pallidum IgM	梅毒ATA/T，蒼白球IGM
JL-FA-193	Systemic Lupus Erythematosus (SLE) Positive	全身性紅斑狼瘡陽性
JL-FA-194	Systemic Lupus Erythematosus (SLE) Negative	全身性紅斑狼瘡陰性
JL-FA-195	TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL)	甲狀腺球蛋白/甲狀腺過氧化物酶陽性
JL-FA-196	TG/TPO Negative	甲狀腺球蛋白/甲狀腺過氧化物酶陰性
JL-FA-197	TTG (Tissue Transglutaminase)	組織轉(zhuǎn)谷氨酰胺酶
JL-FA-198	TTG (Tissue Transglutaminase) IgA	組織轉(zhuǎn)谷氨酰胺酶 IGA
JL-FA-199	ToRCH (Toxo, Rubella, CMV, HSV) Positive	優(yōu)生優(yōu)育（弓形蟲，風(fēng)疹，巨細(xì)胞，單胞）陽性
JL-FA-200	ToRCH (Toxo, Rubella, CMV, HSV) Negative	優(yōu)生優(yōu)育（弓形蟲，風(fēng)疹，巨細(xì)胞，單胞）陰性
JL-FA-201	Toxoplasmosis (Toxo)	弓形蟲病
JL-FA-202	Toxoplasmosis (Toxo) IgG	弓形蟲病IGG
JL-FA-203	Toxoplasmosis (Toxo) IgM	弓形蟲病IGM
JL-FA-204	Thyroglobulin (TG) Positive Plasma	甲狀腺球蛋白陽性血漿
JL-FA-205	Thyroglobulin (TG) Negative	甲狀腺球蛋白陰性
JL-FA-206	Varicella-Zoster Virus (VZV) Negative	水痘-帶狀皰疹病毒陰性
JL-FA-207	Varicella-Zoster Virus (VZV) IgG	水痘-帶狀皰疹病毒IGG
JL-FA-208	Varicella-Zoster Virus (VZV) IgM	水痘-帶狀皰疹病毒IGM
JL-FA-209	West Nile Virus (WNV)	西尼羅河腦炎病毒
JL-FA-210	West Nile Virus (WNV) IgM	西尼羅河腦炎病毒IGM

美國

美國斯隆-凱特琳研究所等處的研究人員創(chuàng)建了一種多能干細(xì)胞基因組編輯平臺：iCRISPR，這一平臺能快速，高效的敲除干細(xì)胞中的基因，而且還能在干細(xì)胞分化過程中，進(jìn)行階段特異性的基因敲除，這將在人類疾病復(fù)雜病理研究中大放異彩。相關(guān)文章發(fā)表于2014年6月12日的《Cell Stem Cell》雜志上。
人體多能干細(xì)胞(hPSCs)不僅能被用于臨床的再生研究應(yīng)用中，而且也能作為解析復(fù)雜性狀和特征的*平臺，闡明其背后的基因和分子途徑。為了實(shí)現(xiàn)這一目的，科學(xué)家們開發(fā)了多種遺傳操控方法，但是這些方法依然存在各種問題，我們需要快速，具有可操控性的生物學(xué)手段。
在這篇文章中，研究人員就利用CRISPR和TALEN，這兩種備受關(guān)注的基因組編輯技術(shù)，研發(fā)出了一種人類多能干細(xì)胞基因組編輯平臺。研究人員將這一平臺稱為iCRISPR。
iCRISPR能用于基因功能喪失研究中，快速，高效的敲除人體多能干細(xì)胞中的等位基因，也可以針對一些精確的疾病模型，通過特定的核苷酸變換，進(jìn)行多能干細(xì)胞純合體敲除。
通過進(jìn)一步實(shí)驗(yàn)，研究人員驗(yàn)證了雙重和三重基因敲除hPSC細(xì)胞系一步法的有效性，同時(shí)也證明了在多能干細(xì)胞分化過程中能進(jìn)行階段特異性誘導(dǎo)基因敲除，這對于發(fā)育生物學(xué)研究來說意義重大。
由此研究人員指出，iCRISPR平臺尤其適合用于解析人類疾病研究中的復(fù)雜遺傳相互作用，以及多效性基因功能，這將有助于進(jìn)行人體多能干細(xì)胞高通量遺傳分析。
除了這項(xiàng)研究之外，去年來自加州大學(xué)舊金山分校的研究人員提出了一個(gè)相似的名稱：CRISPRi，他們發(fā)現(xiàn)當(dāng)缺失核酸內(nèi)切酶活性的Cas9與一種導(dǎo)向RNA共表達(dá)時(shí)候，會產(chǎn)生一種DNA識別復(fù)合物，這種復(fù)合物能特異性干擾轉(zhuǎn)錄延伸，RNA聚合酶結(jié)合，或轉(zhuǎn)錄因子結(jié)合。
由此研究人員研發(fā)出了這種CRISPRi系統(tǒng)，這一系統(tǒng)能有效抑制大腸桿菌中靶向基因的表達(dá)，并且不會出現(xiàn)脫靶效應(yīng)。而且利用CRISPRi，還可以同時(shí)抑制多個(gè)靶基因，這種作用也是可逆。研究人員還證明，該系統(tǒng)也適用于哺乳動(dòng)物細(xì)胞中的基因表達(dá)抑制。
加州大學(xué)圣迭戈分校(University of California, San Diego)醫(yī)學(xué)院研究人員針對自閉癥研究出一套比較新銳的理論，并對其進(jìn)行了實(shí)際測試。研究結(jié)果顯示，自閉癥實(shí)際上是由異常的細(xì)胞通訊導(dǎo)致的，使用問世已逾百年的治療嗜睡癥的藥物，可以恢復(fù)患有自閉癥的老鼠體內(nèi)的細(xì)胞活動(dòng)，消除老鼠的神經(jīng)失調(diào)癥狀。參與實(shí)驗(yàn)的老鼠年齡相當(dāng)于人類30歲左右。相關(guān)研究成果在2014年6月17日的在線刊物《平移精神病學(xué)(Translational Psychiatry)》中發(fā)表。

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Researchers at the U.S.-based Sloan-Caitlin Institute have created iCRISPR, a pluripotent stem cell genomics editing platform that rapidly and efficiently knocks out genes in stem cells and helps them differentiate stem cells during stem cell differentiation, Performing stage-specific knockouts will shine in the complex pathology of human disease. The article appeared in the June 12, 2014 issue of Cell Stem Cell.
Not only can human pluripotent stem cells (hPSCs) be used in clinical regenerative research applications, but also as a unique platform for analyzing complex traits and traits, elucidating the underlying genetic and molecular pathways. To achieve this goal, scientists have developed a variety of genetic manipulation methods, but there are still a variety of problems with these methods, and we need fast, manipulative biological tools.
In this article, researchers developed a human pluripotent stem cell genome editing platform using two well-regarded genome editing technologies, CRISPR and TALEN. The researchers call this platform iCRISPR.
iCRISPR can be used in gene loss studies to rapidly and efficiently knock out alleles in pluripotent human pluripotent stem cells and to target specific models of disease through specific nucleotide transforms for pluripotent stem cell homozygous knocking except.
Through further experiments, the researchers validated the one-step efficacy of double and triple knockout hPSC cell lines, and also demonstrated that stage-specific induction of gene knockdown during pluripotent stem cell differentiation can be performed in developmental biology Meaningful.
As a result, the researchers noted that the iCRISPR platform is particularly well-suited for the analysis of complex genetic interactions in human disease research and pleiotropic gene functions that will facilitate high-throughput genetic analysis of human pluripotent stem cells.
In addition to the study, researchers from the University of California, San Francisco, last year proposed a similar name: CRISPRi, who found that a DNA lacking endonuclease co-expressed with a directing RNA produced a DNA Recognition complexes that specifically interfere with transcriptional elongation, RNA polymerase binding, or transcription factor binding.
As a result, the researchers developed the CRISPRi system, which effectively inhibits the expression of the targeted genes in E. coli and does not show off-target effects. And using CRISPRi, you can also inhibit multiple target genes, this effect is also reversible. The researchers also demonstrated that the system is also suitable for gene expression inhibition in mammalian cells.
Researchers at the University of California, San Diego Medical School developed a set of cutting-edge theories of autism and conducted practical tests. The results show that autism is actually caused by abnormal cell communication, the use of more than a century has come out of the treatment of narcolepsy drugs, can restore autism in mice with cell activity in vivo, to eliminate symptoms of neurological disorders in mice . The age of the mice involved in the experiment is about 30 years old. Relevant research results are published in the June 17, 2014 online translation "Translational Psychiatry."

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