The autumn of November 3, 2017 is the best time to hold group events and strengthen the cohesion of the company. Guangzhou Jianlun Biotechnology Co., Ltd. upholds the concepts and attitudes of solidarity, fraternity, mutual aid, dedication, collaboration, and innovation. To improve the physical fitness of employees and strengthen corporate culture, it actively participates in the Games organized by this Science Park.

At 2 o'clock in the afternoon, in the sun, in the song, on the field, the first fun games of Panyu Innovation and Technology Park kicked off! With the high voice of the host, the crowds on the court lined up in neat rows. The team leader stood in the front of the team holding up the signs of each representative team. The participating athletes were eagerly arranged in the ranks and waiting for the start of the sports meeting. Then, the leader of the Science Park and the leader of the Guangzhou Mountaineering Association made a speech and wished the Games a success!

After the opening ceremony, under the leadership of the host, the athletes completed the warm-up exercise. The upcoming game is a rousing game. The company's first competition program is to test the coordination of the body and teamwork thunderbolt. As the whistle sounded, six colleagues carefully waved the balloons on the drums with a concerted pace and rhythm. The two colleagues were waiting for their help and were ready to pick up the flunging balloons. With nervousness and excitement, every colleague is working hard to complete the game. With the sound of the referee's ending, colleagues were relaxed, but due to lack of exercise, our performance on this project was not satisfactory. The company’s leader, Zhan Zhan, encouraged everyone at this time to cheer up morale and achieved better results in the next game.

At three o'clock in the afternoon, the colleagues of Jianlun Biology were engaged in a penalties game. Accompanied by cheers, I saw my colleagues kick one exciting goal after another and the score went up. In the end, Jianlun Bios achieved good results in the top five on this project. During the intermission, Zhan summoned everyone to a brief summary and encouraged everyone to continue their efforts to achieve better performance. Sure enough, in the following tortoise-bitch races and super-shooting sessions, colleagues performed better and better, demonstrating the positive appearance of Jianlun Biocorp. and the corporate culture of solidarity and cooperation.

At five o'clock in the afternoon, as the last athlete crossed the finish line, the game also came to a close. In the next award ceremony, the winning teams and athletes received commendation and prizes. The sports event was over, but the success and spirit gained through the games will continue to circulate, and it will become a shining landscape on the path of Guangzhou Jianlun Biosciences!

努力，我們一直在路上，明天會更好！

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【公司名稱】廣州健侖生物科技有限公司

【市場部】楊永漢
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【騰訊】
【公司地址】廣州市清華科技園健新基地番禺石樓鎮(zhèn)健啟路63號二期2幢101-103室

(metlproteinse,MP)類，如膠原酶IV、基質(zhì)降解酶、透明質(zhì)酸酶.惡性腫瘤的發(fā)生、發(fā)展、侵襲和轉(zhuǎn)移常常伴有細胞外基質(zhì) (extrcellulr mtrix,ECM)及其細胞表面受體表達的變化。正常肝細胞沒有基膜，也不表達層粘連蛋白(lminin,LN)的特異性整合素族受體αβ；而在肝細胞癌(humn heptocellulr crcinom,HCC)組織中，LN和αβ不僅表達水平升高，呈明顯的共分布，而且其高水平表達與肝癌患者的預后呈負相關，提示 HCC細胞可能通過αβ受體接受來自LN的信號，從而對肝癌細胞的侵襲行為起著不可忽視的作用。肝癌的發(fā)病過程中往往早期就出現(xiàn)門靜脈侵襲、肝內(nèi)轉(zhuǎn)移以及肝外肺臟和骨組織的轉(zhuǎn)移，肝癌的侵襲、轉(zhuǎn)移和術后復發(fā)是影響患者預后的主要因素?；|(zhì)金屬蛋白酶 (mtrix met-lloproteinses,MMPs)對ECM的降解是腫瘤細胞侵襲和轉(zhuǎn)移的關鍵環(huán)節(jié)之一，多種惡性腫瘤都伴有MMPs分泌水平和活性的增高。細胞外基質(zhì)(ECM)是組成間質(zhì)和上皮血管中基質(zhì)的不溶性結(jié)構(gòu)成分，主要有膠原蛋白、彈性蛋白、蛋白多糖和糖蛋白等。
(metylproteinse, MP) class, such as collagenase IV, matrix degrading enzyme, hyaluronidase. The occurrence, development, invasion, and metastasis of malignant tumors are often accompanied by expression of extracellular matrix (ECM) and its cell surface receptors. The change. Normal hepatocytes do not have a basement membrane and do not express laminin (LN)-specific integrin receptor αβ; whereas in hepatocellular carcinoma (HCC), LN and αβ not only express higher levels of expression. It is highly co-distribution, and its high-level expression is negatively correlated with the prognosis of patients with liver cancer, suggesting that HCC cells may receive signals from LN through the αβ receptor, and thus play an important role in the invasion behavior of hepatoma cells. In the process of liver cancer, portal vein invasion, intrahepatic metastasis, and extrahepatic lung and bone metastasis often occur early. The invasion, metastasis, and postoperative recurrence of liver cancer are the main factors affecting the prognosis of patients. The degradation of ECM by matrix metalloproteinases (MMPs) is one of the key steps in the invasion and metastasis of tumor cells. Many malignant tumors are accompanied by an increase in the secretion level and activity of MMPs. The extracellular matrix (ECM) is the insoluble structural component that constitutes the matrix in the interstitial and epithelial blood vessels, and is mainly composed of collagen, elastin, proteoglycans and glycoproteins.

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